Liver fibrosis is a potentially reversible pathophysiological event, leading to excess deposition of extracellular matrix (ECM) components and taking place as the net result of liver fibrogenesis, a dynamic and highly integrated process occurring during chronic liver injury of any etiology. Liver fibrogenesis and fibrosis, together with chronic inflammatory response, are primarily involved in the progression of chronic liver diseases (CLD). As is well known, a major role in fibrogenesis and fibrosis is played by activated myofibroblasts (MFs), as well as by macrophages and other hepatic cell populations involved in CLD progression. In the present review, we will focus the attention on the emerging pathogenic role of hypoxia, hypoxia-inducible factors (HIFs) and related mediators in the fibrogenic progression of CLD.

Hypoxia, Hypoxia-Inducible Factors and Liver Fibrosis

Foglia Beatrice;Novo Erica;Protopapa Francesca;Maggiora Marina;Bocca Claudia;Cannito Stefania;Parola Maurizio
2021-01-01

Abstract

Liver fibrosis is a potentially reversible pathophysiological event, leading to excess deposition of extracellular matrix (ECM) components and taking place as the net result of liver fibrogenesis, a dynamic and highly integrated process occurring during chronic liver injury of any etiology. Liver fibrogenesis and fibrosis, together with chronic inflammatory response, are primarily involved in the progression of chronic liver diseases (CLD). As is well known, a major role in fibrogenesis and fibrosis is played by activated myofibroblasts (MFs), as well as by macrophages and other hepatic cell populations involved in CLD progression. In the present review, we will focus the attention on the emerging pathogenic role of hypoxia, hypoxia-inducible factors (HIFs) and related mediators in the fibrogenic progression of CLD.
2021
10:1764
1
27
https://www.mdpi.com/2073-4409/10/7/1764/pdf
hypoxia; hypoxia-inducible factors; liver fibrosis; liver fibrogenesis; chronic liver diseases
Foglia Beatrice, Novo Erica, Protopapa Francesca, Maggiora Marina, Bocca Claudia, Cannito Stefania, Parola Maurizio
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1795027
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