Vitamin D is a fat-soluble vitamin, which is obtained by conversion of 7-dehydrocholesterol in the skin by UV ray and by diet. Its role on bone mineralization has been known for over two hundred years, while its non-skeletal effects have been acknowledged only in the last few years. The discovery of important Vitamin D properties on the innate and adaptive immune system created a lot of interest in a potential role of Vitamin D on diseases characterized by heightened inflammation and oxidative response, and impaired antimicrobial response, such as asthma and chronic obstructive pulmonary disease (COPD). Recent studies have demonstrated that Vitamin D and its deficiency have a number of biological effects which are potentially important in altering the pathogenesis and severity of both asthma and COPD. Vitamin D may improve lung function and response to steroids therapy, reduce airway remodeling and disease exacerbations. The aim of this study is to review the role of Vitamin D in asthma and COPD.

The immunobiological and clinical role of Vitamin D in obstructive lung diseases

Solidoro P.;Bellocchia M.;Facchini F.
2016

Abstract

Vitamin D is a fat-soluble vitamin, which is obtained by conversion of 7-dehydrocholesterol in the skin by UV ray and by diet. Its role on bone mineralization has been known for over two hundred years, while its non-skeletal effects have been acknowledged only in the last few years. The discovery of important Vitamin D properties on the innate and adaptive immune system created a lot of interest in a potential role of Vitamin D on diseases characterized by heightened inflammation and oxidative response, and impaired antimicrobial response, such as asthma and chronic obstructive pulmonary disease (COPD). Recent studies have demonstrated that Vitamin D and its deficiency have a number of biological effects which are potentially important in altering the pathogenesis and severity of both asthma and COPD. Vitamin D may improve lung function and response to steroids therapy, reduce airway remodeling and disease exacerbations. The aim of this study is to review the role of Vitamin D in asthma and COPD.
MINERVA MEDICA
107
3
12
19
25-hydroxyvitamin D; Asthma; COPD; Treatment of asthma; Treatment of COPD; Vitamin D
Solidoro P.; Bellocchia M.; Facchini F.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/1801434
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