The aim of this study is to quantitatively investigate, at the preclinical level, the extent of Gd retention in the CNS, and peripheral organs, of immune-mediated murine models (Experimental Autoimmune Encephalomyelitis -EAE) of Multiple Sclerosis, compared to control animals, upon the injection of gadodiamide. The influence of the Gadolinium Based Contrast Agent administration timing during the course of EAE development is also monitored.

Analysis of the Gadolinium retention in the Experimental Autoimmune Encephalomyelitis (EAE) murine model of Multiple Sclerosis

Di Gregorio, Enza;Parolisi, Roberta;Atlante, Sandra;Buffo, Annalisa;Bertolotto, Antonio;Aime, Silvio;Gianolio, Eliana
Last
2021

Abstract

The aim of this study is to quantitatively investigate, at the preclinical level, the extent of Gd retention in the CNS, and peripheral organs, of immune-mediated murine models (Experimental Autoimmune Encephalomyelitis -EAE) of Multiple Sclerosis, compared to control animals, upon the injection of gadodiamide. The influence of the Gadolinium Based Contrast Agent administration timing during the course of EAE development is also monitored.
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Experimental Autoimmune Encephalomyelitis; Gadodiamide; Gadolinium based contrast agents; Gadolinium retention; Multiple Sclerosis
Furlan, Chiara; Montarolo, Francesca; Di Gregorio, Enza; Parolisi, Roberta; Atlante, Sandra; Buffo, Annalisa; Bertolotto, Antonio; Aime, Silvio; Gianolio, Eliana
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1801815
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