The treatment of patients with brain metastases (BM) is an important unmet need as, until recently, patients with BM were excluded from clinical studies of systemic therapies. The emergence of molecular targeted therapies has allowed a new treatment approach in patients with targetable mutations, and many of these agents have shown promising intracranial efficacy in lung cancer, breast cancer and melanoma. This editorial summarises the most important new developments and considers the remaining challenges in the treatment of BM.
Brain metastases - clinical challenges and recent advances
Soffietti R.
2019-01-01
Abstract
The treatment of patients with brain metastases (BM) is an important unmet need as, until recently, patients with BM were excluded from clinical studies of systemic therapies. The emergence of molecular targeted therapies has allowed a new treatment approach in patients with targetable mutations, and many of these agents have shown promising intracranial efficacy in lung cancer, breast cancer and melanoma. This editorial summarises the most important new developments and considers the remaining challenges in the treatment of BM.
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