Multiple Myeloma (MM) is a biologically heterogenous plasma-cell disorder. In this study we aimed at dissecting the functional impact on transcriptome of gene mutations, copy-number abnormalities (CNAs), and chromosomal rearrangements (CRs). Moreover, we applied a geno-transcriptomic approach to identify specific biomarkers for personalized treatments.

Functional impact of genomic complexity on the transcriptome of Multiple Myeloma

Ziccheddu, Bachisio
First
;
Oliva, Stefania;D'Agostino, Mattia;
2021

Abstract

Multiple Myeloma (MM) is a biologically heterogenous plasma-cell disorder. In this study we aimed at dissecting the functional impact on transcriptome of gene mutations, copy-number abnormalities (CNAs), and chromosomal rearrangements (CRs). Moreover, we applied a geno-transcriptomic approach to identify specific biomarkers for personalized treatments.
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https://clincancerres.aacrjournals.org/content/early/2021/09/14/1078-0432.CCR-20-4366
https://doi.org/10.1158/1078-0432.ccr-20-4366
https://www.ncbi.nlm.nih.gov/pmc/?term=PMC7612071
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7612071/pdf/EMS135419.pdf
Ziccheddu, Bachisio; Da Via, Matteo Claudio; Lionetti, Marta; Maeda, Akihiro; Morlupi, Silvia; Dugo, Matteo; Todoerti, Katia; Oliva, Stefania; D'Agostino, Mattia; Corradini, Paolo; Landgren, Ola; Iorio, Francesco; Pettine, Loredana; Pompa, Alessandra; Manzoni, Martina; Baldini, Luca; Neri, Antonino; Maura, Francesco; Bolli, Niccolò
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Descrizione: [RESTRICTED Access - PUBLISHED Vsn.] Ziccheddu B et al. Clin Cancer Res. 2021 Dec 1;27(23):6479-6490. doi: 10.1158/1078-0432.CCR-20-4366. Epub 2021 Sep 15. PMID: 34526359; PMCID: PMC7612071. © 2021 American Association for Cancer Research. Available at: https://clincancerres.aacrjournals.org/content/early/2021/09/14/1078-0432.CCR-20-4366 | https://doi.org/10.1158/1078-0432.ccr-20-4366
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1804572
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