Multiple Myeloma (MM) is a biologically heterogenous plasma-cell disorder. In this study we aimed at dissecting the functional impact on transcriptome of gene mutations, copy-number abnormalities (CNAs), and chromosomal rearrangements (CRs). Moreover, we applied a geno-transcriptomic approach to identify specific biomarkers for personalized treatments.
Functional impact of genomic complexity on the transcriptome of Multiple Myeloma
Ziccheddu, BachisioFirst
;Oliva, Stefania;D'Agostino, Mattia;
2021-01-01
Abstract
Multiple Myeloma (MM) is a biologically heterogenous plasma-cell disorder. In this study we aimed at dissecting the functional impact on transcriptome of gene mutations, copy-number abnormalities (CNAs), and chromosomal rearrangements (CRs). Moreover, we applied a geno-transcriptomic approach to identify specific biomarkers for personalized treatments.
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[PUBLISHED Vsn.] Ziccheddu et al - 2021 - Functional Impact of Genomic Complexity.pdf
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Descrizione: [RESTRICTED Access - PUBLISHED Vsn.] Ziccheddu B et al. Clin Cancer Res. 2021 Dec 1;27(23):6479-6490. doi: 10.1158/1078-0432.CCR-20-4366. Epub 2021 Sep 15. PMID: 34526359; PMCID: PMC7612071. © 2021 American Association for Cancer Research. Available at: https://clincancerres.aacrjournals.org/content/early/2021/09/14/1078-0432.CCR-20-4366 | https://doi.org/10.1158/1078-0432.ccr-20-4366
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