Inflammation is a biological response of the immune system to harmful stimuli. Importantly, inflammation is also a hallmark of several human diseases such as cancer or diabetes. Novel drugs to treat this response are constantly researched, but the formulation is usually forgotten. Cyclodextrins (CDs) are a well-known excipient for complexing and drug delivery. Anti-inflammatory drugs and bioactive compounds with similar activities have been favored from these CD processes. CDs also illustrate anti-inflammatory activity per se. This review tried to describe the capacities of CDs in this field, and is divided into two parts: Firstly, a short description of the inflammation disease (causes, symptoms, treatment) is explained; secondly, the effects of different CDs alone or forming inclusion complexes with drugs or bioactive compounds are discussed.

Cyclodextrins as Anti-inflammatory Agents: Basis, Drugs and Perspectives

Lucia Appleton, Silvia;Caldera, Fabrizio;Trotta, Francesco;
2021

Abstract

Inflammation is a biological response of the immune system to harmful stimuli. Importantly, inflammation is also a hallmark of several human diseases such as cancer or diabetes. Novel drugs to treat this response are constantly researched, but the formulation is usually forgotten. Cyclodextrins (CDs) are a well-known excipient for complexing and drug delivery. Anti-inflammatory drugs and bioactive compounds with similar activities have been favored from these CD processes. CDs also illustrate anti-inflammatory activity per se. This review tried to describe the capacities of CDs in this field, and is divided into two parts: Firstly, a short description of the inflammation disease (causes, symptoms, treatment) is explained; secondly, the effects of different CDs alone or forming inclusion complexes with drugs or bioactive compounds are discussed.
BIOMOLECULES
11
9
1384
1398
https://www.mdpi.com/2218-273X/11/9/1384/htm
cyclodextrins, inflammation, drug, review, bioactivity
Lucia Appleton, Silvia; Navarro-Orcajada, Silvia; Martínez-Navarro, Francisco Juan; Caldera, Fabrizio; López-Nicolás, José Manuel; Trotta, Francesco; Matencio, Adrián
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/1807375
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