Bortezomib-based induction followed by high-dose melphalan (200 mg/m2) and autologous stem-cell transplantation (MEL200-ASCT) and maintenance treatment with lenalidomide alone is the current standard of care for young and fit patients with newly diagnosed multiple myeloma. We aimed to evaluate the efficacy and safety of different carfilzomib-based induction and consolidation approaches with or without transplantation and of maintenance treatment with carfilzomib plus lenalidomide versus lenalidomide alone in newly diagnosed multiple myeloma.
Carfilzomib with cyclophosphamide and dexamethasone or lenalidomide and dexamethasone plus autologous transplantation or carfilzomib plus lenalidomide and dexamethasone, followed by maintenance with carfilzomib plus lenalidomide or lenalidomide alone for patients with newly diagnosed multiple myeloma (FORTE): a randomised, open-label, phase 2 trial
Gay, Francesca
Co-first
;Bertamini, Luca;D'Agostino, Mattia;Capra, Andrea;Boccadoro, MarioLast
2021-01-01
Abstract
Bortezomib-based induction followed by high-dose melphalan (200 mg/m2) and autologous stem-cell transplantation (MEL200-ASCT) and maintenance treatment with lenalidomide alone is the current standard of care for young and fit patients with newly diagnosed multiple myeloma. We aimed to evaluate the efficacy and safety of different carfilzomib-based induction and consolidation approaches with or without transplantation and of maintenance treatment with carfilzomib plus lenalidomide versus lenalidomide alone in newly diagnosed multiple myeloma.File in questo prodotto:
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[PUBLISHED Vsn and Suppl Appendix] - Gay et al - 2021 - Lancet Oncol - FORTE trial.pdf
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Descrizione: [Restricted access - Published Vsn. and Suppl. Appendix 1 and 2] Gay F. et al. Lancet Oncol . 2021 Dec;22(12):1705-1720. doi: 10.1016/S1470-2045(21)00535-0. Epub 2021 Nov 11. © 2021 Elsevier Ltd. All rights reserved. Available at: https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(21)00535-0/ppt | https://doi.org/10.1016/s1470-2045(21)00535-0
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[Author Vsn and Suppl Appendix] Gay et al - 2021 - Lancet Oncol - FORTE trial - Post-print c.pdf
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Descrizione: [Restricted Access - Post-print Author Vsn. and Suppl. Appendix 1 and 2] Gay F. et al. Lancet Oncol . 2021 Dec;22(12):1705-1720. doi: 10.1016/S1470-2045(21)00535-0. Epub 2021 Nov 11. © 2021 Elsevier Ltd. All rights reserved. The published version is available at: https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(21)00535-0/ppt | https://doi.org/10.1016/s1470-2045(21)00535-0
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[Pre-print Vsn and Suppl Appendix] Gay et al - 2021 - Lancet Oncol - FORTE trial - Pre-print.pdf
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Descrizione: [Pre-print Vsn. and Suppl. Appendix] Gay F. et al. Lancet Oncol . 2021 Dec;22(12):1705-1720. doi: 10.1016/S1470-2045(21)00535-0. Epub 2021 Nov 11. © 2021 Elsevier Ltd. All rights reserved. The published version is available at: https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(21)00535-0/ppt | https://doi.org/10.1016/s1470-2045(21)00535-0
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