Introduction. Breast Cancer is one of the main problem in clinical oncology. Adequate treatment of the disease includes appropriate use of antineoplastic drugs. The concept is fundamental in order to get and maintain optimal results. The aim of our study was to focus the importance of the hospital Pharmacist to verify the adherence of the protocols to the concept of total dose, Dose Intensity and Dose Density. An innovative database Access was buit to organize and process the data. Materials and methods. In this observational retrospective study we considered 283 patients. The study was conducted in the Pharmacy located in an Oncologic center. We considered one-year study, from December 1st 2017 to November 30th 2018. We analyze 43 different therapeutic schemes and 4809 administrations divided into the three main classical treatments setting: neoadjuvant, adjuvant and metastatic. Results. In neoadjuvant setting we considered 51 patients, average age 51 years old. The Performance Status (PS) was included between 0 an1 values. 901 administrations were considered and the Dose Intensity is divided as follow: 96% of the patients received an administration with 100% of planned dose, 4% received a dosage reduction. In adjuvant setting we included 159 women. Average age was 53 years old. The PS was included between 0 and 1 values. The study focus the attention on 2716 administrations. Dose intensity was as follow: 92% with a 100% dosage, 8% a reduction of the dosage infuse. The metastatic cohort included 73 patients with an average age of 59 years old. Patients considered had PS value from 0 to 3. For this population were analyze 1192 administrations. The distribution of Dose Intensity in palliative chemotherapy was: 76% of 100% dosage and 24% received a dosage reduction. Conclusion. This work highlights the importance of designing IT tools, such as databases created ad hoc, which allow the pharmacist to assess the appropriateness of antiblastic prescriptions and the percentage of decrease compared to the optimal dose intensity.
The importance of Dose Intensity in neoadjuvant, adjuvant and palliative chemotherapy in breast cancer
Comandone T.;Capilli M.
;Baratta F.;Brusa P.
2021-01-01
Abstract
Introduction. Breast Cancer is one of the main problem in clinical oncology. Adequate treatment of the disease includes appropriate use of antineoplastic drugs. The concept is fundamental in order to get and maintain optimal results. The aim of our study was to focus the importance of the hospital Pharmacist to verify the adherence of the protocols to the concept of total dose, Dose Intensity and Dose Density. An innovative database Access was buit to organize and process the data. Materials and methods. In this observational retrospective study we considered 283 patients. The study was conducted in the Pharmacy located in an Oncologic center. We considered one-year study, from December 1st 2017 to November 30th 2018. We analyze 43 different therapeutic schemes and 4809 administrations divided into the three main classical treatments setting: neoadjuvant, adjuvant and metastatic. Results. In neoadjuvant setting we considered 51 patients, average age 51 years old. The Performance Status (PS) was included between 0 an1 values. 901 administrations were considered and the Dose Intensity is divided as follow: 96% of the patients received an administration with 100% of planned dose, 4% received a dosage reduction. In adjuvant setting we included 159 women. Average age was 53 years old. The PS was included between 0 and 1 values. The study focus the attention on 2716 administrations. Dose intensity was as follow: 92% with a 100% dosage, 8% a reduction of the dosage infuse. The metastatic cohort included 73 patients with an average age of 59 years old. Patients considered had PS value from 0 to 3. For this population were analyze 1192 administrations. The distribution of Dose Intensity in palliative chemotherapy was: 76% of 100% dosage and 24% received a dosage reduction. Conclusion. This work highlights the importance of designing IT tools, such as databases created ad hoc, which allow the pharmacist to assess the appropriateness of antiblastic prescriptions and the percentage of decrease compared to the optimal dose intensity.
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