Background: Acute peripheral trauma is a controversial risk factor for idiopathic dystonia. Materials and methods: We retrospectively analyzed data from the Italian Dystonia Registry regarding the occurrence of acute peripheral trauma severe enough to require medical attention in 1382 patients with adult-onset idiopathic dystonia and 200 patients with acquired adult-onset dystonia. Results: Patients with idiopathic and acquired dystonia showed a similar burden of peripheral trauma in terms of the number of patients who experienced trauma (115/1382 vs. 12/200, p = 0.3) and the overall number of injuries (145 for the 1382 idiopathic patients and 14 for the 200 patients with secondary dystonia, p = 0.2). Most traumas occurred before the onset of idiopathic or secondary dystonia but only a minority of such injuries (14 in the idiopathic group, 2 in the acquired group, p = 0.6) affected the same body part as that affected by dystonia. In the idiopathic group, the elapsed time between trauma and dystonia onset was 8.1 ± 9.2 years; only six of the 145 traumas (4.1%) experienced by 5/1382 idiopathic patients (0.36%) occurred one year or less before dystonia onset; in the acquired dystonia group, the two patients experienced prior trauma to the dystonic body part 5 and 6 years before dystonia development. Discussion and conclusion: Our data suggest that the contribution of peripheral acute trauma to idiopathic dystonia is negligible, if anything, and likely involves only a small subset of patients.

Does acute peripheral trauma contribute to idiopathic adult-onset dystonia?

Zibetti M.;Marchese R.;Demonte G.;Petracca M.;Modugno N.
2020

Abstract

Background: Acute peripheral trauma is a controversial risk factor for idiopathic dystonia. Materials and methods: We retrospectively analyzed data from the Italian Dystonia Registry regarding the occurrence of acute peripheral trauma severe enough to require medical attention in 1382 patients with adult-onset idiopathic dystonia and 200 patients with acquired adult-onset dystonia. Results: Patients with idiopathic and acquired dystonia showed a similar burden of peripheral trauma in terms of the number of patients who experienced trauma (115/1382 vs. 12/200, p = 0.3) and the overall number of injuries (145 for the 1382 idiopathic patients and 14 for the 200 patients with secondary dystonia, p = 0.2). Most traumas occurred before the onset of idiopathic or secondary dystonia but only a minority of such injuries (14 in the idiopathic group, 2 in the acquired group, p = 0.6) affected the same body part as that affected by dystonia. In the idiopathic group, the elapsed time between trauma and dystonia onset was 8.1 ± 9.2 years; only six of the 145 traumas (4.1%) experienced by 5/1382 idiopathic patients (0.36%) occurred one year or less before dystonia onset; in the acquired dystonia group, the two patients experienced prior trauma to the dystonic body part 5 and 6 years before dystonia development. Discussion and conclusion: Our data suggest that the contribution of peripheral acute trauma to idiopathic dystonia is negligible, if anything, and likely involves only a small subset of patients.
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Dystonia; Injury; Trauma; Acute Disease; Aged; Dystonic Disorders; Female; Humans; Italy; Male; Middle Aged; Peripheral Nerve Injuries; Retrospective Studies; Risk Factors; Registries
Defazio G.; Fabbrini G.; Erro R.; Albanese A.; Barone P.; Zibetti M.; Esposito M.; Pellicciari R.; Avanzino L.; Bono F.; Eleopra R.; Bertolasi L.; Altavista M.C.; Cotelli M.S.; Ceravolo R.; Scaglione C.; Bentivoglio A.R.; Cossu G.; Coletti Moja M.; Girlanda P.; Misceo S.; Pisani A.; Mascia M.M.; Ercoli T.; Tinazzi M.; Maderna L.; Minafra B.; Magistrelli L.; Romano M.; Aguggia M.; Tambasco N.; Castagna A.; Cassano D.; Berardelli A.; Ferrazzano G.; Lalli S.; Silvestre F.; Manganelli F.; Di Biasio F.; Marchese R.; Demonte G.; Santangelo D.; Devigili G.; Durastanti V.; Turla M.; Mazzucchi S.; Petracca M.; Oppo V.; Barbero P.; Morgante F.; Di Lazzaro G.; Squintani G.; Modugno N.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/1836990
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