Background: Progressive supranuclear palsy (PSP) is a rare rapidly progressive, neurodegenerative disease characterized by falls and ocular movement disturbances. The use of health-related quality of life (HR-QoL) measures allows assessing changes in health status induced by therapeutic interventions or disease progress in neurodegenerative diseases. The PSP-QoL is a 45-item, self-administered questionnaire designed to evaluate HR-QoL in PSP. Methods and Results: Here, the PSP-QoL was translated into Italian and validated in 190 PSP (96 women and 94 men; mean age ± standard deviation, 72 ± 6.5; mean disease duration, 4.2 ± 2.3) patients diagnosed according to the Movement Disorder Society criteria and recruited in 16 third level movement disorders centers participating in the Neurecanet project. The mean PSP-QoL total score was 77.8 ± 37 (physical subscore, 46.5 ± 18.7; mental subscore, 33.6 ± 19.2). The internal consistency was high (Cronbach’s alpha = 0.954); corrected item-total correlation was > 0.40 for the majority of items. The significant and moderate correlation of the PSP-QoL with other HR-QoL measures as well as with motor and disability assessments indicated adequate convergent validity of the scale. Gender and geographic location presented a significant impact on the PSP-QoL in our sample with women and patients from the South of Italy scoring higher than their counterparts. Conclusion: In conclusion, the Italian version of the PSP-QoL is an easy, reliable and valid tool for assessment of HR-QoL in PSP.

Validation of the Italian version of the PSP Quality of Life questionnaire

Fabbri M.;Santangelo G.;Zappia M.;Zibetti M.;
2019

Abstract

Background: Progressive supranuclear palsy (PSP) is a rare rapidly progressive, neurodegenerative disease characterized by falls and ocular movement disturbances. The use of health-related quality of life (HR-QoL) measures allows assessing changes in health status induced by therapeutic interventions or disease progress in neurodegenerative diseases. The PSP-QoL is a 45-item, self-administered questionnaire designed to evaluate HR-QoL in PSP. Methods and Results: Here, the PSP-QoL was translated into Italian and validated in 190 PSP (96 women and 94 men; mean age ± standard deviation, 72 ± 6.5; mean disease duration, 4.2 ± 2.3) patients diagnosed according to the Movement Disorder Society criteria and recruited in 16 third level movement disorders centers participating in the Neurecanet project. The mean PSP-QoL total score was 77.8 ± 37 (physical subscore, 46.5 ± 18.7; mental subscore, 33.6 ± 19.2). The internal consistency was high (Cronbach’s alpha = 0.954); corrected item-total correlation was > 0.40 for the majority of items. The significant and moderate correlation of the PSP-QoL with other HR-QoL measures as well as with motor and disability assessments indicated adequate convergent validity of the scale. Gender and geographic location presented a significant impact on the PSP-QoL in our sample with women and patients from the South of Italy scoring higher than their counterparts. Conclusion: In conclusion, the Italian version of the PSP-QoL is an easy, reliable and valid tool for assessment of HR-QoL in PSP.
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Clinical trials; Parkinsonism; Progressive supranuclear palsy; Quality of life; Aged; Aged, 80 and over; Female; Humans; Italy; Male; Psychometrics; Reproducibility of Results; Self Report; Supranuclear Palsy, Progressive; Quality of Life
Picillo M.; Cuoco S.; Amboni M.; Bonifacio F.P.; Bruschi F.; Carotenuto I.; De Micco R.; De Rosa A.; Del Prete E.; Di Biasio F.; Elifani F.; Erro R.; Fabbri M.; Falla M.; Franco G.; Frosini D.; Galantucci S.; Lazzeri G.; Magistrelli L.; Malaguti M.C.; Milner A.V.; Minafra B.; Olivola E.; Pilotto A.; Rascuna C.; Rizzetti M.C.; Schirinzi T.; Borroni B.; Ceravolo R.; Di Fonzo A.; Marchese R.; Mercuri N.B.; Modugno N.; Nicoletti A.; Padovani A.; Santangelo G.; Stefani A.; Tessitore A.; Volonte M.A.; Zangaglia R.; Zappia M.; Zibetti M.; Barone P.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/1836992
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