Epithelial ovarian cancer (EOC) is the leading cause of death among women affected by gynaecological malignancies. Most patients show advanced disease at diagnosis (FIGO stage III-IV) and, despite the introduction of new therapeutic options, most women experience relapses. In most cases, recurrence is abdominal-pelvic; however, EOC can occasionally metastasize to distant organs, including the central nervous system. The incidence of brain metastases (BMs) from EOC is low, but it has grown over time; currently, there are no follow-up strategies available. In the last decade, a few biomarkers able to predict the risk of developing BMs from OC or as potential therapeutic targets have been investigated by several authors; to date, none have entered clinical practice. The purpose of this review is to offer a summary on the role of the most relevant predictors of central nervous system (CNS) involvement (hormone receptors; BRCA; MRD1; PD-1/PD-L1) and to highlight possible therapeutic strategies for the management of metastatic brain disease in EOC.

Biomarkers of central nervous system involvement from epithelial ovarian cancer

Scotto G.;Borella F.;Turinetto M.;Tuninetti V.;Valsecchi A. A.;Giannone G.;Cosma S.;Benedetto C.;Valabrega G.
2021

Abstract

Epithelial ovarian cancer (EOC) is the leading cause of death among women affected by gynaecological malignancies. Most patients show advanced disease at diagnosis (FIGO stage III-IV) and, despite the introduction of new therapeutic options, most women experience relapses. In most cases, recurrence is abdominal-pelvic; however, EOC can occasionally metastasize to distant organs, including the central nervous system. The incidence of brain metastases (BMs) from EOC is low, but it has grown over time; currently, there are no follow-up strategies available. In the last decade, a few biomarkers able to predict the risk of developing BMs from OC or as potential therapeutic targets have been investigated by several authors; to date, none have entered clinical practice. The purpose of this review is to offer a summary on the role of the most relevant predictors of central nervous system (CNS) involvement (hormone receptors; BRCA; MRD1; PD-1/PD-L1) and to highlight possible therapeutic strategies for the management of metastatic brain disease in EOC.
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https://pubmed.ncbi.nlm.nih.gov/34943916/
Biomarker; Brain metastases; Ovarian cancer; Biomarkers, Tumor; Brain Neoplasms; Carcinoma, Ovarian Epithelial; Central Nervous System; Female; Humans; Receptors, Cell Surface; Signal Transduction
Scotto G.; Borella F.; Turinetto M.; Tuninetti V.; Valsecchi A.A.; Giannone G.; Cosma S.; Benedetto C.; Valabrega G.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1844886
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