Purpose: The aim of this pilot study was to clarify the acceptability and clinical efficacy of an oxygen-enriched oil-based gel for treatment of angular cheilitis. Methods: A class IIb medical preparation, packaged in appropriate syringes, was tested. Patients were instructed how to use the gel for 10 days: finger rub application (3 times daily) on the dried lesion after meals, without eating, drinking, or speaking for at least 30 min thereafter. The Wilcoxon signed-rank test was used to assess whether there were any differences in the distributions of reported pain and lesion dimension. A microbiological examination was also performed with oral swabs; chi-squared test was used to compare the difference in the presence of microorganisms before and after treatment. Results: Thirty patients were treated. A significant improvement in reported outcome and a significant reduction in the initially measured larg-est dimension of the lesion were observed after use of the clinical protocol. Additionally, a significant reduction in the pathogen count was found. Conclusion: Even if with limitations, data showed that this medical preparation facilitated prompt recovery from reported pain, without adverse reactions. Further work with a larger study population, and possibly a randomized control medication, will be needed.

A single-center prospective pilot open-label study to assess the efficacy of topical application of an oxygen-enriched oil for the treatment of angular cheilitis

Arduino P. G.;Cabras M.;Macciotta A.;Longhi F.;Gambino A.;Broccoletti R.
2022

Abstract

Purpose: The aim of this pilot study was to clarify the acceptability and clinical efficacy of an oxygen-enriched oil-based gel for treatment of angular cheilitis. Methods: A class IIb medical preparation, packaged in appropriate syringes, was tested. Patients were instructed how to use the gel for 10 days: finger rub application (3 times daily) on the dried lesion after meals, without eating, drinking, or speaking for at least 30 min thereafter. The Wilcoxon signed-rank test was used to assess whether there were any differences in the distributions of reported pain and lesion dimension. A microbiological examination was also performed with oral swabs; chi-squared test was used to compare the difference in the presence of microorganisms before and after treatment. Results: Thirty patients were treated. A significant improvement in reported outcome and a significant reduction in the initially measured larg-est dimension of the lesion were observed after use of the clinical protocol. Additionally, a significant reduction in the pathogen count was found. Conclusion: Even if with limitations, data showed that this medical preparation facilitated prompt recovery from reported pain, without adverse reactions. Further work with a larger study population, and possibly a randomized control medication, will be needed.
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Angular cheilitis; Hyper-oxidized oil; Microbiology; Treatment; Humans; Oxygen; Pilot Projects; Prospective Studies; Treatment Outcome; Cheilitis
Arduino P.G.; Cabras M.; Macciotta A.; Longhi F.; Gambino A.; Broccoletti R.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1846060
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