Increased Placental Anti‐Oxidant Response in Asymptomatic and Symptomatic COVID‐19 Third‐Trimester Pregnancies

Despite Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2) ‐induced Oxidative Stress (OxS) being well documented in different organs, the molecular pathways underlying placental OxS in late‐pregnancy women with SARS‐COV‐2 infection are poorly understood. Herein, we performed an observational study to determine whether placentae of women testing positive for SARS‐CoV‐2 during the third trimester of pregnancy showed redox-related alterations involving Catalase (CAT) and Superoxide Dismutase (SOD) antioxidant enzymes as well as placenta morphological anomalies relative to a cohort of healthy pregnant women. Next, we evaluated if placental redox‐related alterations and mitochondria pathological changes were correlated with the presence of maternal symptoms. We observed ultrastructural alterations of placental mitochondria accompanied by increased levels of oxidative stress markers Thiobarbituric Acid Reactive Substances (TBARS) and Hypoxia Inducible Factor‐1 α (HIF‐1α) in SARS‐CoV‐2 women during the third trimester of pregnancy. Importantly, we found an increase in placental CAT and SOD antioxidant enzymes accompanied by physiological neonatal outcomes. Our findings strongly suggest a placenta‐mediated OxS inhibition in response to SARS‐CoV‐2 infection, thus contrasting the cytotoxic profile caused by Coronavirus Disease 2019 (COVID‐19).