Aberrant signaling in myeloproliferative neoplasms may arise from alterations in genes coding for signal transduction proteins or epigenetic regulators. Both mutated and normal cells co-operate, altering fragile balances in bone marrow niches and fueling persistent inflammation through paracrine or systemic signals. Despite the hopes placed in targeted therapies, myeloid pro-liferative neoplasms remain incurable diseases in patients not eligible for stem cell transplantation. Due to the emergence of drug resistance, patient management is often very difficult in the long term. Unexpected connections among signal transduction pathways highlighted in neoplastic cells sug-gest new strategies to overcome neoplastic cell adaptation.

Understanding Aberrant Signaling to Elude Therapy Escape Mechanisms in Myeloproliferative Neoplasms

Poggio P.;Morotti A.
;
Brancaccio M.
Co-last
;
Lucchesi A.
Co-last
2022-01-01

Abstract

Aberrant signaling in myeloproliferative neoplasms may arise from alterations in genes coding for signal transduction proteins or epigenetic regulators. Both mutated and normal cells co-operate, altering fragile balances in bone marrow niches and fueling persistent inflammation through paracrine or systemic signals. Despite the hopes placed in targeted therapies, myeloid pro-liferative neoplasms remain incurable diseases in patients not eligible for stem cell transplantation. Due to the emergence of drug resistance, patient management is often very difficult in the long term. Unexpected connections among signal transduction pathways highlighted in neoplastic cells sug-gest new strategies to overcome neoplastic cell adaptation.
14
4
972
994
Aurora A; Cell signaling; Drug resistance; JAK2; Myeloproliferative neoplasms; ROCK
Bochicchio M.T.; Di Battista V.; Poggio P.; Carra G.; Morotti A.; Brancaccio M.; Lucchesi A.
File in questo prodotto:
File Dimensione Formato  
Bochicchio et al., Understanding Aberrant Signaling to Elude Therapy Escape, Cancers, 2022.pdf

Accesso aperto

Tipo di file: PDF EDITORIALE
Dimensione 7.66 MB
Formato Adobe PDF
7.66 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1856903
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 0
  • ???jsp.display-item.citation.isi??? 0
social impact