Aim: To describe oral cavity changes in patients who underwent a hematopoietic stem cell transplantation (HSCT). Methods and results: A group of 32 patients was studied after a mean period of 48.8 months (±11.22) from HSCT; oral, dental, and periodontal status were collected and compared with those of healthy matched controls. Unstimulated whole salivary flow (UWS) and salivary pH were also measured. A validated questionnaire (EORTC QLQH&N-35) was used for reported quality of life. Fifty-nine percent of patients were affected by chronic graft-versus-host disease (cGVHD). Dental health and periodontal status were statistically worse than in controls (P =.003 and P =.008, respectively). Regarding the HSCT group, UWS was statistically lower, and EORTC QLQH&N-35 significantly higher than those reported in controls (P =.000 for both). There was no statistical correlation between hypo-salivation and conditioning, presence of cGVHD, type of medication used before and after transplantation, and time of follow-up. A reduction in salivary pH has been noted only for patients with erosive oral lesions. Conclusion: The oral cavity of HSCT patients appeared to undergo substantial modifications and the quality of life was deeply compromised.

Oral health status after hematopoietic stem cell transplantations: Outcomes from an adult Italian population

Arduino P. G.;Gambino A.;Giaccone L.;Carbone M.;Carrozzo M.;Broccoletti R.;Conrotto D.
2022-01-01

Abstract

Aim: To describe oral cavity changes in patients who underwent a hematopoietic stem cell transplantation (HSCT). Methods and results: A group of 32 patients was studied after a mean period of 48.8 months (±11.22) from HSCT; oral, dental, and periodontal status were collected and compared with those of healthy matched controls. Unstimulated whole salivary flow (UWS) and salivary pH were also measured. A validated questionnaire (EORTC QLQH&N-35) was used for reported quality of life. Fifty-nine percent of patients were affected by chronic graft-versus-host disease (cGVHD). Dental health and periodontal status were statistically worse than in controls (P =.003 and P =.008, respectively). Regarding the HSCT group, UWS was statistically lower, and EORTC QLQH&N-35 significantly higher than those reported in controls (P =.000 for both). There was no statistical correlation between hypo-salivation and conditioning, presence of cGVHD, type of medication used before and after transplantation, and time of follow-up. A reduction in salivary pH has been noted only for patients with erosive oral lesions. Conclusion: The oral cavity of HSCT patients appeared to undergo substantial modifications and the quality of life was deeply compromised.
2022
42
6
585
591
hematopoietic stem cell transplantation; hyposalivation; oral graft-versus-host disease; oral health; oral status
Arduino P.G.; Gambino A.; Giaccone L.; Suria M.; Carbone M.; Carrozzo M.; Broccoletti R.; Conrotto D.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1867139
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