Growing evidence suggests that energy metabolism and inflammation are closely linked and that cross-talk between these processes is fundamental to the pathogenesis of many human diseases. However, the molecular mechanisms underlying these observations are still poorly understood. Here we describe the key role of ATP-citrate lyase (ACLY) in inflammation. We find that ACLY mRNA and protein levels markedly and quickly increase in activated macrophages. Importantly, ACLY activity inhibition as well as ACLY gene silencing lead to reduced nitric oxide, reactive oxygen species and prostaglandin E2 inflammatory mediators. In conclusion, we present a direct role for ACLY in macrophage inflammatory metabolism. © 2013 Elsevier Inc.

ATP-citrate lyase is essential for macrophage inflammatory response

Infantino V.
First
;
Menga A.
Last
2013-01-01

Abstract

Growing evidence suggests that energy metabolism and inflammation are closely linked and that cross-talk between these processes is fundamental to the pathogenesis of many human diseases. However, the molecular mechanisms underlying these observations are still poorly understood. Here we describe the key role of ATP-citrate lyase (ACLY) in inflammation. We find that ACLY mRNA and protein levels markedly and quickly increase in activated macrophages. Importantly, ACLY activity inhibition as well as ACLY gene silencing lead to reduced nitric oxide, reactive oxygen species and prostaglandin E2 inflammatory mediators. In conclusion, we present a direct role for ACLY in macrophage inflammatory metabolism. © 2013 Elsevier Inc.
2013
440
1
105
111
https://www.sciencedirect.com/science/article/pii/S0006291X13015088?via=ihub
ATP-citrate lyase; Immunometabolism; Inflammation; Nitric oxide; Prostaglandin E2; Reactive oxygen species
Infantino V.; Iacobazzi V.; Palmieri F.; Menga A.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1869080
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