A straightforward and efficient protocol to promote the metalation/anionic Fries rearrangements of O-aryl carbamates, using for the first time a lithium amide as metalating agent under aerobic/ambient-friendly reaction conditions, is reported. This approach enables the sustainable preparation of salicylamide derivatives with high levels of chemoselectivity within ultrafast reaction times, working at room temperature in the presence of air/moisture, and using environmentally responsible cyclopentyl methyl ether as a solvent. Furthermore, the regioselective manipulation of O-2-tolyl carbamates has been accomplished using interchangeably alkyllithiums or lithium amides, with an unexpected beneficial contribution from the employment of biorenewable protic eutectic mixtures as non-innocent reaction media.

Chemo- and Regioselective Anionic Fries Rearrangement Promoted by Lithium Amides under Aerobic Conditions in Sustainable Reaction Media

Ghinato, Simone;De Nardi, Federica;Bolzoni, Paola;Antenucci, Achille;Blangetti, Marco
;
Prandi, Cristina
2022

Abstract

A straightforward and efficient protocol to promote the metalation/anionic Fries rearrangements of O-aryl carbamates, using for the first time a lithium amide as metalating agent under aerobic/ambient-friendly reaction conditions, is reported. This approach enables the sustainable preparation of salicylamide derivatives with high levels of chemoselectivity within ultrafast reaction times, working at room temperature in the presence of air/moisture, and using environmentally responsible cyclopentyl methyl ether as a solvent. Furthermore, the regioselective manipulation of O-2-tolyl carbamates has been accomplished using interchangeably alkyllithiums or lithium amides, with an unexpected beneficial contribution from the employment of biorenewable protic eutectic mixtures as non-innocent reaction media.
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e202201154
e202201154
https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/chem.202201154
Fries rearrangement; alkali metal; lithium amide; metalation; sustainable chemistry
Ghinato, Simone; De Nardi, Federica; Bolzoni, Paola; Antenucci, Achille; Blangetti, Marco; Prandi, Cristina
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1869102
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