Reliable and affordable prognostic and predictive biomarkers for urothelial carcinoma treated with immunotherapy may allow patients' outcome stratification and drive therapeutic options. The SAUL trial investigated the safety and efficacy of atezolizumab in a real-world setting on 1004 patients with locally advanced or metastatic urothelial carcinoma who progressed to one to three prior systemic therapies.

Immune-inflammatory biomarkers as prognostic factors for immunotherapy in pretreated advanced urinary tract cancer patients: an analysis of the Italian SAUL cohort

De Giorgi, U;Masini, C;Buttigliero, C;
2021-01-01

Abstract

Reliable and affordable prognostic and predictive biomarkers for urothelial carcinoma treated with immunotherapy may allow patients' outcome stratification and drive therapeutic options. The SAUL trial investigated the safety and efficacy of atezolizumab in a real-world setting on 1004 patients with locally advanced or metastatic urothelial carcinoma who progressed to one to three prior systemic therapies.
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LDH; PD-1; PD-L1; biomarker; immune-checkpoint inhibitor; immunotherapy; neutrophil-to-lymphocyte ratio (NLR); prognostic; systemic immune-inflammation index (SII); urothelial carcinoma; Biomarkers; Humans; Immunotherapy; Italy; Prognosis; Carcinoma, Transitional Cell; Lung Neoplasms; Urinary Bladder Neoplasms; Urologic Neoplasms
Fornarini, G; Rebuzzi, S E; Banna, G L; Calabrò, F; Scandurra, G; De Giorgi, U; Masini, C; Baldessari, C; Naglieri, E; Caserta, C; Manacorda, S; Maruzzo, M; Milella, M; Buttigliero, C; Tambaro, R; Ermacora, P; Morelli, F; Nolè, F; Astolfi, C; Sternberg, C N
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1870235
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