Genomic instability is a hallmark of cancer and targeting DNA damage response (DDR) is emerging as a promising therapeutic strategy in different solid tumors. The effectiveness of targeting DDR in colorectal cancer has not been extensively explored.

Targeting the DNA Damage Response Pathways and Replication Stress in Colorectal Cancer

Reilly, Nicole M;Buzo, Kristi;Mariella, Elisa;Lorenzato, Annalisa;Grasso, Gaia;Corti, Giorgio;Di Nicolantonio, Federica;Bardelli, Alberto;Arena, Sabrina
2022-01-01

Abstract

Genomic instability is a hallmark of cancer and targeting DNA damage response (DDR) is emerging as a promising therapeutic strategy in different solid tumors. The effectiveness of targeting DDR in colorectal cancer has not been extensively explored.
2022
OF1
OF16
Durinikova, Erika; Reilly, Nicole M; Buzo, Kristi; Mariella, Elisa; Chilà, Rosaria; Lorenzato, Annalisa; Dias, João M L; Grasso, Gaia; Pisati, Federica; Lamba, Simona; Corti, Giorgio; Degasperi, Andrea; Cancelliere, Carlotta; Mauri, Gianluca; Andrei, Pietro; Linnebacher, Michael; Marsoni, Silvia; Siena, Salvatore; Sartore-Bianchi, Andrea; Nik-Zainal, Serena; Di Nicolantonio, Federica; Bardelli, Alberto; Arena, Sabrina
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1872758
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