Genomic instability is a hallmark of cancer and targeting DNA damage response (DDR) is emerging as a promising therapeutic strategy in different solid tumors. The effectiveness of targeting DDR in colorectal cancer has not been extensively explored.
Targeting the DNA Damage Response Pathways and Replication Stress in Colorectal Cancer
Reilly, Nicole M;Buzo, Kristi;Mariella, Elisa;Lorenzato, Annalisa;Grasso, Gaia;Corti, Giorgio;Di Nicolantonio, Federica;Bardelli, Alberto;Arena, Sabrina
2022-01-01
Abstract
Genomic instability is a hallmark of cancer and targeting DNA damage response (DDR) is emerging as a promising therapeutic strategy in different solid tumors. The effectiveness of targeting DDR in colorectal cancer has not been extensively explored.
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