Pheochromocytomas and paragangliomas are endocrine tumors belonging to the family of neural crest cell-derived neoplasms. They have an extremely variable clinical course, characterized by a non-negligible percentage of relapse and/or metastasis after radical surgery. To date, there are no reliable methods to predict the metastatic potential of these neoplasms, despite several clinical, molecular, and histopathological factors that have been extensively studied in the literature as predictors of the recurrence and/or metastasis in these neoplasms with different performances and results. In this review, we aimed to discuss and analyze the most important clinical and histopathological tools for predicting recurrence risk in patients affected by pheochromocytomas or paragangliomas. Thus, we compared the main available predictive models, exploring their applications in stratifying patients' risks. In conclusion, we underlined the importance of simple and validated tools to better define disease aggressiveness and establish tailored patients' treatments and follow-ups.

Clinical and Pathological Tools for Predicting Recurrence and/or Metastasis in Patients with Pheochromocytoma and Paraganglioma

Bima, Chiara
First
;
Bioletto, Fabio;Lopez, Chiara;Bollati, Martina;Arata, Stefano;Procopio, Matteo;Gesmundo, Iacopo;Ghigo, Ezio;Maccario, Mauro;Parasiliti-Caprino, Mirko
Last
2022

Abstract

Pheochromocytomas and paragangliomas are endocrine tumors belonging to the family of neural crest cell-derived neoplasms. They have an extremely variable clinical course, characterized by a non-negligible percentage of relapse and/or metastasis after radical surgery. To date, there are no reliable methods to predict the metastatic potential of these neoplasms, despite several clinical, molecular, and histopathological factors that have been extensively studied in the literature as predictors of the recurrence and/or metastasis in these neoplasms with different performances and results. In this review, we aimed to discuss and analyze the most important clinical and histopathological tools for predicting recurrence risk in patients affected by pheochromocytomas or paragangliomas. Thus, we compared the main available predictive models, exploring their applications in stratifying patients' risks. In conclusion, we underlined the importance of simple and validated tools to better define disease aggressiveness and establish tailored patients' treatments and follow-ups.
10
8
1813
1825
malignancy; paraganglioma; pheochromocytoma; predictive model; prognostic factors; recurrence
Bima, Chiara; Bioletto, Fabio; Lopez, Chiara; Bollati, Martina; Arata, Stefano; Procopio, Matteo; Gesmundo, Iacopo; Ghigo, Ezio; Maccario, Mauro; Parasiliti-Caprino, Mirko
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1873864
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