Low grade serous carcinoma of the ovary and peritoneum (LGSC) is characterized by low response rates to chemotherapy and by MAPK pathway alterations. Phase II/III clinical trials tested different MEK inhibitors (MEKis) in this complex malignancy, with heterogenous results. Purpose of this systematic review and meta-analysis is to define activity and efficacy of these agents and explore differences in clinical outcomes related to RAS/RAF mutational status.

MEK inhibitor as single agent in low grade serous ovarian and peritoneal cancer: a systematic review and meta-analysis

Valsecchi, Anna Amela;Valabrega, Giorgio;Tuninetti, Valentina;Di Maio, Massimo;
2022-01-01

Abstract

Low grade serous carcinoma of the ovary and peritoneum (LGSC) is characterized by low response rates to chemotherapy and by MAPK pathway alterations. Phase II/III clinical trials tested different MEK inhibitors (MEKis) in this complex malignancy, with heterogenous results. Purpose of this systematic review and meta-analysis is to define activity and efficacy of these agents and explore differences in clinical outcomes related to RAS/RAF mutational status.
2022
aug 24
110
1
7
Binimetinib; Chemo-resistance; Low grade ovarian cancer; MEK inhibitors; Selumetinib; Trametinib
Musacchio, Lucia; Valsecchi, Anna Amela; Salutari, Vanda; Valabrega, Giorgio; Camarda, Floriana; Tuninetti, Valentina; Giannone, Gaia; Bartoletti, Michele; Marchetti, Claudia; Pignata, Sandro; Fagotti, Anna; Scambia, Giovanni; Di Maio, Massimo; Lorusso, Domenica
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1875361
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