COVID‑19: different waves and different outcomes

The COVID‐19 pandemic forced us to improve our skills in the management of a new multiorgan syndrome.1 The first wave caught us unarmed, fac‐ ing the virus and its manifestations with a non– evidence‐based approach: the lack of high‐quality data supporting the use of any drug to fight the vi‐ rus was counterbalanced by the need to treat our patients.2 The accumulation of information and knowledge on the COVID‐19 pathology, improve‐ ments in clinical management and therapeutic interventions, and the decrease in SARS‐CoV‐2 virulence went hand‐in‐hand with a reduction in mortality.3 A reduction in hospitalization and in‐ tensive care unit (ICU) admission rates as well as mortality were observed during the second and third waves almost all over the world