In JACOB trial, pertuzumab added to trastuzumab-chemotherapy did not significantly improve survival of patients with HER2-positive metastatic gastric cancer, despite 3.3 months increase versus placebo. HER2 copy number variation (CNV) and AMNESIA panel encompassing primary resistance alterations (KRAS/PIK3CA/MET mutations, KRAS/EGFR/MET amplifications) may improve patients' selection for HER2 inhibition.

HER2 copy number and resistance mechanisms in patients with HER2-positive advanced gastric cancer receiving initial trastuzumab-based therapy in JACOB trial

Bellomo, Sara Erika;Corso, Simona;Berrino, Enrico;Migliore, Cristina;Marchio', Caterina;Giordano, Silvia
Last
2023-01-01

Abstract

In JACOB trial, pertuzumab added to trastuzumab-chemotherapy did not significantly improve survival of patients with HER2-positive metastatic gastric cancer, despite 3.3 months increase versus placebo. HER2 copy number variation (CNV) and AMNESIA panel encompassing primary resistance alterations (KRAS/PIK3CA/MET mutations, KRAS/EGFR/MET amplifications) may improve patients' selection for HER2 inhibition.
2023
Inglese
Esperti anonimi
29
3
571
580
Online ahead of print
SPAGNA
SVIZZERA
1 – prodotto con file in versione Open Access (allegherò il file al passo 6 - Carica)
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Pietrantonio, Filippo; Manca, Paolo; Bellomo, Sara Erika; Corso, Simona; Raimondi, Alessandra; Berrino, Enrico; Morano, Federica; Migliore, Cristina; ...espandi
info:eu-repo/semantics/article
open
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1880636
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