Among 128 adult people living with HIV and no neurological conditions confounding the cerebrospinal fluid results, the presence of HSV-1 chronic infection (detected either by serology or PCR), but not of HSV-2 and VZV, independently associated with higher odds of blood-brain barrier impairment, abnormally increased cerebrospinal fluid levels of tau and phosphorylated-181 tau, and decreased concentrations of fragments 1-42 of beta amyloid compared to the seronegative counterpart. These associations were even stronger for seropositive participants with a positive history of at least one symptomatic reactivation of HSV-1.

Seropositivity and reactivations of HSV-1, but not of HSV-2 nor VZV, associate with altered blood-brain barrier, beta amyloid, and tau proteins in people living with HIV

Trunfio, Mattia
First
;
Di Girolamo, Laura;Ponzetta, Laura;Atzori, Cristiana;Di Perri, Giovanni;Calcagno, Andrea
Last
2022-01-01

Abstract

Among 128 adult people living with HIV and no neurological conditions confounding the cerebrospinal fluid results, the presence of HSV-1 chronic infection (detected either by serology or PCR), but not of HSV-2 and VZV, independently associated with higher odds of blood-brain barrier impairment, abnormally increased cerebrospinal fluid levels of tau and phosphorylated-181 tau, and decreased concentrations of fragments 1-42 of beta amyloid compared to the seronegative counterpart. These associations were even stronger for seropositive participants with a positive history of at least one symptomatic reactivation of HSV-1.
2022
1
6
Alzheimer’s dementia; Blood–brain barrier; Cerebrospinal fluid biomarkers; HIV; Herpes simplex; Varicella zoster
Trunfio, Mattia; Di Girolamo, Laura; Ponzetta, Laura; Russo, Marco; Burdino, Elisa; Imperiale, Daniele; Atzori, Cristiana; Di Perri, Giovanni; Calcagno, Andrea
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1881265
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