NF-kappa B is diffusely recognized as a transcriptional factor able to modulate the expression of various genes involved in a broad spectrum of cellular functions, including proliferation, survival and migration. NF-kappa B is, however, also acting outside the nucleus and beyond its ability to binds to DNA. NF-kappa B is indeed found to localize inside different cellular organelles, such as mitochondria, endoplasmic reticulum, Golgi and nucleoli, where it acts through different partners in mediating various biological functions. Here, we discuss the relationship linking NF-kappa B to the cellular organelles, and how this crosstalk between cellular organelles and NF-kappa B signalling may be evaluated for anticancer therapies.

Shedding Light on NF-κB Functions in Cellular Organelles

Avalle, Lidia;Brancaccio, Mara;Morotti, Alessandro
2022-01-01

Abstract

NF-kappa B is diffusely recognized as a transcriptional factor able to modulate the expression of various genes involved in a broad spectrum of cellular functions, including proliferation, survival and migration. NF-kappa B is, however, also acting outside the nucleus and beyond its ability to binds to DNA. NF-kappa B is indeed found to localize inside different cellular organelles, such as mitochondria, endoplasmic reticulum, Golgi and nucleoli, where it acts through different partners in mediating various biological functions. Here, we discuss the relationship linking NF-kappa B to the cellular organelles, and how this crosstalk between cellular organelles and NF-kappa B signalling may be evaluated for anticancer therapies.
2022
10
841646
841655
Golgi; NF-κB—nuclear factor kappa B; anticancer therapy; endoplasmic reticulum (ER); lysosome; mitochondria
Carrà, Giovanna; Avalle, Lidia; Seclì, Laura; Brancaccio, Mara; Morotti, Alessandro
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1881621
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