Glypican-3 (GPC-3) is a heparan sulfate proteoglycan overexpressed by hepatocellular carcinoma (HCC) cells. Several studies highlighted the diagnostic and prognostic value of GPC-3 expression in liver tissue, while data on the reliability of serum GPC-3 are limited and conflicting. We aimed to evaluate the prognostic value of serum GPC-3 in patients with HCC.
Serum glypican-3 for the prediction of survival in patients with hepatocellular carcinoma
Nicolosi, AuroraFirst
;Gaia, Silvia;Risso, Alessandra;Rosso, Chiara;Rolle, Emanuela;Abate, Maria L;Olivero, Antonella;Armandi, Angelo;Ribaldone, Davide G;Fagoonee, Sharmila;Pellicano, Rinaldo;Saracco, Giorgio M;Bugianesi, Elisabetta;Caviglia, Gian P
Last
2022-01-01
Abstract
Glypican-3 (GPC-3) is a heparan sulfate proteoglycan overexpressed by hepatocellular carcinoma (HCC) cells. Several studies highlighted the diagnostic and prognostic value of GPC-3 expression in liver tissue, while data on the reliability of serum GPC-3 are limited and conflicting. We aimed to evaluate the prognostic value of serum GPC-3 in patients with HCC.
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