Long-term cancer survivors are at high risk of developing cardiac complications from the treatments, both systemic agents and thoracic irradiation, received to cure the primary tumor. Modern advances, particularly in the field of radiotherapy, aim to reduce the risk of cardiovascular disease. Also, new diagnostic tools increasingly improve their efficacy in early detection of the preclinical treatment-induced cardiac damage. In this review, we summarize the mechanisms of radiotherapy- and chemotherapy-induced cardiac injury, the available clinical data, the strategies to mitigate cardiac exposure with modern radiotherapy and the current diagnostic tools for an early detection and prompt management of these complications in long-term cancer survivors.

Cardiometabolic Risk, Part 1: Chemotherapy and Radiotherapy - Old Foes Still Threatening Cancer Survivors?

Andreis A.;Cerrato M.;Vella A.;Ricardi U.;Levis M.
2021-01-01

Abstract

Long-term cancer survivors are at high risk of developing cardiac complications from the treatments, both systemic agents and thoracic irradiation, received to cure the primary tumor. Modern advances, particularly in the field of radiotherapy, aim to reduce the risk of cardiovascular disease. Also, new diagnostic tools increasingly improve their efficacy in early detection of the preclinical treatment-induced cardiac damage. In this review, we summarize the mechanisms of radiotherapy- and chemotherapy-induced cardiac injury, the available clinical data, the strategies to mitigate cardiac exposure with modern radiotherapy and the current diagnostic tools for an early detection and prompt management of these complications in long-term cancer survivors.
2021
Frontiers of Hormone Research
S. Karger AG
54
115
129
978-3-318-06790-3
978-3-318-06791-0
Humans; Antineoplastic Agents; Cancer Survivors; Cardiovascular Diseases; Neoplasms
Maraldo M.V.; Andreis A.; Iamundo De Cumis I.; Cerrato M.; Vella A.; Ricardi U.; Levis M.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1883552
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