Four epidemiologic studies have assessed the association between nut intake and pancreatic cancer risk with contradictory results. The present study aims to investigate the relation between nut intake (including seeds) and pancreatic ductal adenocarcinoma (PDAC) risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Cox proportional hazards models were used to estimate hazards ratio (HR) and 95% confidence intervals (95% CI) for nut intake and PDAC risk. Information on intake of nuts was obtained from the EPIC country-specific dietary questionnaires. After a mean follow-up of 14 years, 476,160 participants were eligible for the present study and included 1,283 PDAC cases. No association was observed between consumption of nuts and PDAC risk (highest intake vs nonconsumers: HR, 0.89; 95% CI, 0.72-1.10; p-trend = 0.70). Furthermore, no evidence for effect-measure modification was observed when different subgroups were analyzed. Overall, in EPIC, the highest intake of nuts was not statistically significantly associated with PDAC risk.

Consumption of nuts and seeds and pancreatic ductal adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition

Sciannameo, Veronica;
2020-01-01

Abstract

Four epidemiologic studies have assessed the association between nut intake and pancreatic cancer risk with contradictory results. The present study aims to investigate the relation between nut intake (including seeds) and pancreatic ductal adenocarcinoma (PDAC) risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Cox proportional hazards models were used to estimate hazards ratio (HR) and 95% confidence intervals (95% CI) for nut intake and PDAC risk. Information on intake of nuts was obtained from the EPIC country-specific dietary questionnaires. After a mean follow-up of 14 years, 476,160 participants were eligible for the present study and included 1,283 PDAC cases. No association was observed between consumption of nuts and PDAC risk (highest intake vs nonconsumers: HR, 0.89; 95% CI, 0.72-1.10; p-trend = 0.70). Furthermore, no evidence for effect-measure modification was observed when different subgroups were analyzed. Overall, in EPIC, the highest intake of nuts was not statistically significantly associated with PDAC risk.
2020
146
1
76
84
EPIC; diet; intake; nuts; pancreatic cancer; prospective cohort study; seeds
Obón-Santacana, Mireia; Luján-Barroso, Leila; Freisling, Heinz; Naudin, Sabine; Boutron-Ruault, Marie-Christine; Mancini, Francesca Romana; Rebours, Vinciane; Kühn, Tilman; Katzke, Verena; Boeing, Heiner; Tjønneland, Anne; Olsen, Anja; Overvad, Kim; Lasheras, Cristina; Rodríguez-Barranco, Miguel; Amiano, Pilar; Santiuste, Carmen; Ardanaz, Eva; Khaw, Kay-Thee; Wareham, Nicholas J; Schmidt, Julie A; Aune, Dagfinn; Trichopoulou, Antonia; Thriskos, Paschalis; Peppa, Eleni; Masala, Giovanna; Grioni, Sara; Tumino, Rosario; Panico, Salvatore; Bueno-de-Mesquita, Bas; Sciannameo, Veronica; Vermeulen, Roel; Sonestedt, Emily; Sund, Malin; Weiderpass, Elisabete; Skeie, Guri; González, Carlos A; Riboli, Elio; Duell, Eric J
File in questo prodotto:
File Dimensione Formato  
2019 - Obon-santacana - EPIC_nuts.pdf

Accesso aperto

Tipo di file: PDF EDITORIALE
Dimensione 550.68 kB
Formato Adobe PDF
550.68 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1885199
Citazioni
  • ???jsp.display-item.citation.pmc??? 3
  • Scopus 10
  • ???jsp.display-item.citation.isi??? 8
social impact