This chapter summarizes the state of art of the past and ongoing efforts in the setting of prevention of brain metastases. PCI has a definite role in the prevention of relapses in the brain of patients with SCLC, in particular for those who completely responded to chemotherapy and radiotherapy. Conversely, PCI is able to reduce the incidence of brain metastasis but does not improve overall survival in NSCLC. The new frontier of prevention is represented by the use of molecular agents with activity on macrometastases, but an efficacy on micrometastases as well needs to be investigated in adequately designed prevention trials.
Prevention strategies for brain mestasases
Soffietti, R.;Pellerino, A.;Ruda', R.
2020-01-01
Abstract
This chapter summarizes the state of art of the past and ongoing efforts in the setting of prevention of brain metastases. PCI has a definite role in the prevention of relapses in the brain of patients with SCLC, in particular for those who completely responded to chemotherapy and radiotherapy. Conversely, PCI is able to reduce the incidence of brain metastasis but does not improve overall survival in NSCLC. The new frontier of prevention is represented by the use of molecular agents with activity on macrometastases, but an efficacy on micrometastases as well needs to be investigated in adequately designed prevention trials.
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