Transfusion-dependent Diamond-Blackfan anaemia (DBA) patients rapidly develop iron overload and frequently experience cardiac complications. The report by Lecornec and colleagues offers useful details on indications and the management of deferiprone, a highly efficient chelator in removing excess cardiac iron but associated with a high risk of agranulocytosis in DBA patients.Commentary on: Nicolas Lecornec and colleagues: Agranulocytosis in patients with Diamond-Blackfan anaemia treated with deferiprone for post-transfusion iron overload: A retrospective study of the French DBA cohort. British Journal of Haematology 2022.
Diamond-Blackfan anaemia with iron overload: A serious issue
Quarello, Paola
First
;Ramenghi, Ugo;Fagioli, FrancaLast
2022-01-01
Abstract
Transfusion-dependent Diamond-Blackfan anaemia (DBA) patients rapidly develop iron overload and frequently experience cardiac complications. The report by Lecornec and colleagues offers useful details on indications and the management of deferiprone, a highly efficient chelator in removing excess cardiac iron but associated with a high risk of agranulocytosis in DBA patients.Commentary on: Nicolas Lecornec and colleagues: Agranulocytosis in patients with Diamond-Blackfan anaemia treated with deferiprone for post-transfusion iron overload: A retrospective study of the French DBA cohort. British Journal of Haematology 2022.
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