Little is known of the course of COVID-19 and the antibody response to infection or vaccination in patients with hairy-cell leukaemia (HCL). Among a total of 58 HCL cases we studied in these regards, 37 unvaccinated patients, mostly enjoying a relatively long period free from anti-leukaemic treatment, developed COVID-19 between March 2020 and December 2021 with a usually favourable outcome (fatality rate: 5/37, 14%); however, active leukaemia, older age and more comorbidities were associated with a worse course. Postinfection (n = 11 cases) and postvaccination (n = 28) seroconversion consistently developed, except after recent anti-CD20 or venetoclax therapy, correlating with perivaccine B-cell count. Vaccination appeared to protect from severe COVID-19 in 11 patients with breakthrough infection.

SARS-CoV-2 infection and vaccination in patients with hairy-cell leukaemia

Morotti, Alessandro;Romano, Alessandra;Bruna, Riccardo;Massaia, Massimo;Corradini, Paolo;
2022-01-01

Abstract

Little is known of the course of COVID-19 and the antibody response to infection or vaccination in patients with hairy-cell leukaemia (HCL). Among a total of 58 HCL cases we studied in these regards, 37 unvaccinated patients, mostly enjoying a relatively long period free from anti-leukaemic treatment, developed COVID-19 between March 2020 and December 2021 with a usually favourable outcome (fatality rate: 5/37, 14%); however, active leukaemia, older age and more comorbidities were associated with a worse course. Postinfection (n = 11 cases) and postvaccination (n = 28) seroconversion consistently developed, except after recent anti-CD20 or venetoclax therapy, correlating with perivaccine B-cell count. Vaccination appeared to protect from severe COVID-19 in 11 patients with breakthrough infection.
2022
1
6
COVID-19; anti-SARS-CoV-2 vaccination; hairy-cell leukaemia; post-COVID-19 seroconversion
Tiacci, Enrico; Mancini, Alessandro; Marchetti, Monia; D'Elia, Gianna Maria; Candoni, Anna; Morotti, Alessandro; Romano, Alessandra; Gozzetti, Alessandro; Broccoli, Alessandro; De Carolis, Luca; Bruna, Riccardo; Tisi, Maria Chiara; Selleri, Carmine; Capponi, Monia; Vallisa, Daniele; Cattaneo, Chiara; Della Porta, Matteo Giovanni; Busca, Alessandro; Falini, Brunangelo; Massaia, Massimo; Bertù, Lorenza; Pulsoni, Alessandro; Rivela, Paolo; Corradini, Paolo; Passamonti, Francesco
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1891554
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