The synthesis of acetals in acidic natural deep eutectic solvents (NADES), in which the solvent itself participates in the catalytic promotion of the reaction, is reported herein. The reaction is performed under feasible conditions, open air, without the need of external additives, catalysts or water-removing techniques, and it is wide in scope. The products are easily recovered, and the reaction medium is fully recycled and reused without weakening of its catalytic activity after 10 times. Remarkably, the entire process has been realized on gram scale.

Efficient and Low-Impact Acetalization Reactions in Deep Eutectic Solvents

Arnodo, Davide
First
;
Meazzo, Carolina;Baldino, Salvatore;Blangetti, Marco;Prandi, Cristina
2023-01-01

Abstract

The synthesis of acetals in acidic natural deep eutectic solvents (NADES), in which the solvent itself participates in the catalytic promotion of the reaction, is reported herein. The reaction is performed under feasible conditions, open air, without the need of external additives, catalysts or water-removing techniques, and it is wide in scope. The products are easily recovered, and the reaction medium is fully recycled and reused without weakening of its catalytic activity after 10 times. Remarkably, the entire process has been realized on gram scale.
2023
29
36 art e202300820
1
6
https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202300820
acetalization; acid catalysis; deep eutectic solvents; protecting groups; sustainable chemistry
Arnodo, Davide; Meazzo, Carolina; Baldino, Salvatore; Blangetti, Marco; Prandi, Cristina
File in questo prodotto:
File Dimensione Formato  
Manuscript pre-print.pdf

Accesso riservato

Descrizione: Articolo versione pre-referaggio
Tipo di file: PREPRINT (PRIMA BOZZA)
Dimensione 974.55 kB
Formato Adobe PDF
974.55 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
ChemistryAEuropeanJ2023.pdf

Accesso aperto

Descrizione: licenza CC BY-NC-ND 4.0
Tipo di file: PDF EDITORIALE
Dimensione 1.2 MB
Formato Adobe PDF
1.2 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1903632
Citazioni
  • ???jsp.display-item.citation.pmc??? 3
  • Scopus 6
  • ???jsp.display-item.citation.isi??? 4
social impact