Splanchnic vein thrombosis is a rare but potentially life-threatening manifestation of venous thromboembolism, with challenging implications both at the pathological and therapeutic level. It is frequently associated with liver cirrhosis, but it could also be provoked by myeloproliferative disorders, cancer of various gastroenterological origin, abdominal infections and thrombophilia. A portion of splanchnic vein thrombosis is still classified as idiopathic. Here, we review the mechanisms of splanchnic vein thrombosis, including new insights on the role of clonal hematopoiesis in idiopathic SVT pathogenesis, with important implications from the therapeutic standpoint.

Shedding Light on the Pathogenesis of Splanchnic Vein Thrombosis

Camerlo, Sofia;Ligato, Jacopo;Rosati, Giorgio;Russo, Isabella;De Gobbi, Marco;Morotti, Alessandro
2023-01-01

Abstract

Splanchnic vein thrombosis is a rare but potentially life-threatening manifestation of venous thromboembolism, with challenging implications both at the pathological and therapeutic level. It is frequently associated with liver cirrhosis, but it could also be provoked by myeloproliferative disorders, cancer of various gastroenterological origin, abdominal infections and thrombophilia. A portion of splanchnic vein thrombosis is still classified as idiopathic. Here, we review the mechanisms of splanchnic vein thrombosis, including new insights on the role of clonal hematopoiesis in idiopathic SVT pathogenesis, with important implications from the therapeutic standpoint.
2023
24
3
2262
2273
cirrhosis; clonal hematopoiesis; hemostasis; myeloproliferative disorders; splanchnic vein thrombosis
Camerlo, Sofia; Ligato, Jacopo; Rosati, Giorgio; Carrà, Giovanna; Russo, Isabella; De Gobbi, Marco; Morotti, Alessandro
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1904907
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