Cardiovascular Risk Factors and Family History of Major Thrombotic Events in Children with Migraine: A 12-Year Retrospective Single-Centre Study

Background: Migraine is one of the most frequent primary headaches in childhood. The role of thrombotic predisposition in its pathogenesis is debated. Our aim was to analyse the cardiovascular risk factors and family history of major thrombotic events in children with migraine. Methods: Aretrospective, single-centre study was performed over 12 years. Our headache centre record database was screened for migraine with aura (MA) and migraine without aura (MO) on the basis of the ICHD-II (until 2013) and III criteria. A control group of otherwise healthy children was recruited. Descriptive and multivariate analyses are provided; significance was set at p< 0.05. Results: Migraine was diagnosed in 930 children (24.7% MA); 73.3% were 9-14 years old. Children with MA were older (p< 0.001). A family history of cerebral ischemic events at=50 years old was more commonly reported by children with MA than those with MO (p< 0.001) and those in the control group(p= 0.001). Children with MA showed a higher risk of a family history of cerebral ischemic events at=50 years old than children with MO (OR: 2.6) and those in the control group (OR: 3.1). When comparing the family history of DVT, we observed a significantly increased risk for MA vs. MO(OR: 2.9). Conclusion: A family history of cerebral ischemic events at=50 years old leads to an increased risk of MA. Further studies are needed to explore such an association.