Achieving high molecular complexity can be not trivial, but the exploitation of domino reactions provides an atom- and step-economical method to reach this target. Over the past decades, a lot of efforts have been put on the development of photocatalytic cascades employing both metal-based and purely organic catalysts. Despite the effectiveness of these protocols, catalyst- and additive-free light-induced domino reactions are gaining momentum thank to their efficiency, operational simplicity and sustainability. The increasing number of papers published on this field in the last years is a proof of the appeal of these transformations. In this Review, we discuss domino and multicomponent reactions mediated by light with a focus on photocatalyst- and additive-free processes. The most recent advances in the synthesis of complex nitrogen-, oxygen-, sulphur- and selenium-heterocycles together with multicomponent cascades are analysed with an emphasis on both experimental and mechanistic studies.

Light-Induced Domino and Multicomponent Reactions: How to Reach Molecular Complexity without a Catalyst

Polyssena Renzi
;
Jacopo Scarfiello;Alberto Lanfranco;Annamaria Deagostino
2023-01-01

Abstract

Achieving high molecular complexity can be not trivial, but the exploitation of domino reactions provides an atom- and step-economical method to reach this target. Over the past decades, a lot of efforts have been put on the development of photocatalytic cascades employing both metal-based and purely organic catalysts. Despite the effectiveness of these protocols, catalyst- and additive-free light-induced domino reactions are gaining momentum thank to their efficiency, operational simplicity and sustainability. The increasing number of papers published on this field in the last years is a proof of the appeal of these transformations. In this Review, we discuss domino and multicomponent reactions mediated by light with a focus on photocatalyst- and additive-free processes. The most recent advances in the synthesis of complex nitrogen-, oxygen-, sulphur- and selenium-heterocycles together with multicomponent cascades are analysed with an emphasis on both experimental and mechanistic studies.
2023
26
41
e202300713
e202300713
https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/ejoc.202300713
Domino Reactions, Multicomponent Reactions, light, catalyst free
Polyssena Renzi, Jacopo Scarfiello, Alberto Lanfranco, Annamaria Deagostino
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1945245
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