Advances in cancer medicines have resulted in tangible health impacts, but the magnitude of benefits of approved cancer medicines could vary greatly. Health Technology Assessment (HTA) is a multidisciplinary process used to inform resource allocation through a systematic value assessment of health technology. This paper reviews the challenges in conducting HTA for cancer medicines arising from oncology trial designs and uncertainties of safety-efficacy data.

Implications of Oncology Trial Design and Uncertainties in Efficacy-Safety Data on Health Technology Assessments

Genazzani, Armando;
2022-01-01

Abstract

Advances in cancer medicines have resulted in tangible health impacts, but the magnitude of benefits of approved cancer medicines could vary greatly. Health Technology Assessment (HTA) is a multidisciplinary process used to inform resource allocation through a systematic value assessment of health technology. This paper reviews the challenges in conducting HTA for cancer medicines arising from oncology trial designs and uncertainties of safety-efficacy data.
2022
29
8
5774
5791
MCBS; accelerated approval; cancer medicines; dis-investments; health economics; health technology assessment; value; Biomarkers; Cost-Benefit Analysis; Humans; Quality of Life; Neoplasms; Technology Assessment; Biomedical
Trapani, Dario; Tay-Teo, Kiu; Tesch, Megan E; Roitberg, Felipe; Sengar, Manju; Altuna, Sara C; Hassett, Michael J; Genazzani, Armando; Kesselheim, Aaron S; Curigliano, Giuseppe
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1952478
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