: The definition of cell metabolic profile is essential to ensure skeletal muscle fiber heterogeneity and to achieve a proper equilibrium between the self-renewal and commitment of satellite stem cells. Heme sustains several biological functions, including processes profoundly implicated with cell metabolism. The skeletal muscle is a significant heme-producing body compartment, but the consequences of impaired heme homeostasis on this tissue have been poorly investigated. Here, we generate a skeletal-muscle-specific feline leukemia virus subgroup C receptor 1a (FLVCR1a) knockout mouse model and show that, by sustaining heme synthesis, FLVCR1a contributes to determine the energy phenotype in skeletal muscle cells and to modulate satellite cell differentiation and muscle regeneration.

Flvcr1a deficiency promotes heme-based energy metabolism dysfunction in skeletal muscle

Mistretta, Miriam;Fiorito, Veronica;Allocco, Anna Lucia;Ammirata, Giorgia;Digiovanni, Sabrina;Porporato, Paolo Ettore;Miniscalco, Barbara;Crich, Simonetta Geninatti;Riganti, Chiara;Tolosano, Emanuela
2024-01-01

Abstract

: The definition of cell metabolic profile is essential to ensure skeletal muscle fiber heterogeneity and to achieve a proper equilibrium between the self-renewal and commitment of satellite stem cells. Heme sustains several biological functions, including processes profoundly implicated with cell metabolism. The skeletal muscle is a significant heme-producing body compartment, but the consequences of impaired heme homeostasis on this tissue have been poorly investigated. Here, we generate a skeletal-muscle-specific feline leukemia virus subgroup C receptor 1a (FLVCR1a) knockout mouse model and show that, by sustaining heme synthesis, FLVCR1a contributes to determine the energy phenotype in skeletal muscle cells and to modulate satellite cell differentiation and muscle regeneration.
2024
Inglese
Esperti anonimi
43
3
1
20
20
ALAS1; FLVCR1; FLVCR1a; heme; metabolism; skeletal muscle
no
   Disentangling genetic, epigenetic and hormonal regulation of Fe/heme metabolism in the gender-specific nature of NAFLD; finanziato dall’Unione europea – Next Generation EU
   DEFENDER
   Ministero dell'Università e della Ricerca
   2022XJNWRM
1 – prodotto con file in versione Open Access (allegherò il file al passo 6 - Carica)
262
20
Mistretta, Miriam; Fiorito, Veronica; Allocco, Anna Lucia; Ammirata, Giorgia; Hsu, Myriam Y; Digiovanni, Sabrina; Belicchi, Marzia; Napoli, Laura; Rip...espandi
info:eu-repo/semantics/article
open
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1960390
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