Resveratrol is a phytoalexin able to display an array of biological activities. We decided to replace the double bond with a triazole ring using the archetypical click reaction: the Huisgen [3 + 2] cycloaddition. Seventy-two triazole derivatives were synthesized via a parallel combinatorial approach. Preliminary data suggest that this procedure can lead to the synthesis of compounds that display some, but not all, of resveratrol's actions with increased potency. © 2006 American Chemical Society.

Rapid synthesis of triazole-modified resveratrol analogues via click chemistry

Tron G. C.;Sorba G.;Genazzani Armando
Last
2006-01-01

Abstract

Resveratrol is a phytoalexin able to display an array of biological activities. We decided to replace the double bond with a triazole ring using the archetypical click reaction: the Huisgen [3 + 2] cycloaddition. Seventy-two triazole derivatives were synthesized via a parallel combinatorial approach. Preliminary data suggest that this procedure can lead to the synthesis of compounds that display some, but not all, of resveratrol's actions with increased potency. © 2006 American Chemical Society.
2006
49
2
467
470
Pagliai F.; Pirali T.; Del Grosso E.; Di Brisco R.; Tron G.C.; Sorba G.; Genazzani Armando
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1961772
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