A natural pH-sensitive dye, curcumin, and a synthetic pH-sensitive dye, Bromothymol blue, were successfully applied on cotton/polyamide 6 medical dressings. The work addresses two different topics: on the one hand the dyeing process of the medical devices; on the other hand, the evaluation of the dyed medical dressing biocompatibility. Different dye concentrations were tested to find the best dye exhaustion and dye fastness to washing and perspiration. The halochromic test evidenced a pH sensitivity in a range of pH from 5.5 to 8.0 and 8.5. These properties confirmed their possible usage as potential pH textile sensors in the control of skin diseases. The last sections examine the biocompatibility of the prepared medical devices with human skin. MTT assay on in vitro cultures of human epithelial cells (HaCaT keratinocytes) was performed to test the cytotoxicity. In vitro permeation studies with Franz cells were performed as well to evaluate the dye potential accumulation in the skin layers. No cytotoxicity was detected as well as no dye permeation through the skin layers.
Performances and Biocompatibility of Prepared pH-Sensitive Cotton/Polyamide 6 Medical Dressings Dyed with Halochromic Dyes
Cavalli, Roberta;Argenziano, Monica;
2022-01-01
Abstract
A natural pH-sensitive dye, curcumin, and a synthetic pH-sensitive dye, Bromothymol blue, were successfully applied on cotton/polyamide 6 medical dressings. The work addresses two different topics: on the one hand the dyeing process of the medical devices; on the other hand, the evaluation of the dyed medical dressing biocompatibility. Different dye concentrations were tested to find the best dye exhaustion and dye fastness to washing and perspiration. The halochromic test evidenced a pH sensitivity in a range of pH from 5.5 to 8.0 and 8.5. These properties confirmed their possible usage as potential pH textile sensors in the control of skin diseases. The last sections examine the biocompatibility of the prepared medical devices with human skin. MTT assay on in vitro cultures of human epithelial cells (HaCaT keratinocytes) was performed to test the cytotoxicity. In vitro permeation studies with Franz cells were performed as well to evaluate the dye potential accumulation in the skin layers. No cytotoxicity was detected as well as no dye permeation through the skin layers.
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