Fibroblasts play a crucial role in wound healing and skin fibrosis. It is also probably the cell model used to study in vitro photobiomodulation. Our previous in vivo results evidenced a faster recovery in blue-light-treated wounds (410–430 nm). In vitro experiments demonstrated that the lower dose increases cell metabolism, while higher doses (30.9 and 41.2 J/cm2) reduce it. Furthermore, 20.6 J/cm2 affects outward currents and Cytochrome C. Here, we described our preliminary results on the effects of blue LED light on mitochondria and reactive oxygen species production. Globally, our results demonstrated that short-wavelength blue LED light has PBM properties.

Effects of short-wavelength blue-light on fibroblasts. Expermental evidence in wound healing and cutaneous fibrosis

Marco Fraccalvieri;
2023-01-01

Abstract

Fibroblasts play a crucial role in wound healing and skin fibrosis. It is also probably the cell model used to study in vitro photobiomodulation. Our previous in vivo results evidenced a faster recovery in blue-light-treated wounds (410–430 nm). In vitro experiments demonstrated that the lower dose increases cell metabolism, while higher doses (30.9 and 41.2 J/cm2) reduce it. Furthermore, 20.6 J/cm2 affects outward currents and Cytochrome C. Here, we described our preliminary results on the effects of blue LED light on mitochondria and reactive oxygen species production. Globally, our results demonstrated that short-wavelength blue LED light has PBM properties.
2023
21
1
1
6
photobiomodulation; blue light; wound healing; fibroblasts; skin fibrosis
Giada magni, Federica Cherchi, Martina Banchelli, Francesca Tatini, Patrizia Nardini, Daniele Guasti, Elisabetta Coppi, Anna maria Pugliese, Marco Fra...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1968410
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