Mechanisms of Phytoremediation by Resveratrol against Cadmium Toxicity

first_pagesettingsOrder Article Reprints This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessReview Mechanisms of Phytoremediation by Resveratrol against Cadmium Toxicity by Barbara Mognetti 1,*,†ORCID,Francesco Franco 2,†ORCID,Chiara Castrignano 2ORCID,Patrizia Bovolin 1ORCID andGiovanni Nicolao Berta 2ORCID 1 Department of Life Sciences and Systems Biology, University of Turin, Via Accademia Albertina 13, 10123 Turin, Italy 2 Department of Clinical and Biological Sciences, University of Turin, Regione Gonzole 10, 10043 Orbassano, Italy * Author to whom correspondence should be addressed. † These authors contributed equally to this work. Antioxidants 2024, 13(7), 782; https://doi.org/10.3390/antiox13070782 (registering DOI) Submission received: 5 June 2024 / Revised: 24 June 2024 / Accepted: 26 June 2024 / Published: 27 June 2024 (This article belongs to the Special Issue Antioxidant Defenses against Pollution and Other Environmental Stresses) Downloadkeyboard_arrow_down Versions Notes Abstract Cadmium (Cd) toxicity poses a significant threat to human health and the environment due to its widespread occurrence and persistence. In recent years, considerable attention has been directed towards exploring natural compounds with potential protective effects against Cd-induced toxicity. Among these compounds, resveratrol (RV) has emerged as a promising candidate, demonstrating a range of beneficial effects attributed to its antioxidant and anti-inflammatory properties. This literature review systematically evaluates the protective role of RV against Cd toxicity, considering the various mechanisms of action involved. A comprehensive analysis of both in vitro and in vivo studies is conducted to provide a comprehensive understanding of RV efficacy in mitigating Cd-induced damage. Additionally, this review highlights the importance of phytoremediation strategies in addressing Cd contamination, emphasizing the potential of RV in enhancing the efficiency of such remediation techniques. Through the integration of diverse research findings, this review underscores the therapeutic potential of RV in combating Cd toxicity and underscores the need for further investigation to elucidate its precise mechanisms of action and optimize its application in environmental and clinical settings.