The development of an archive of patient-reported outcome measures (PROMs) in oncology: The Italian PRO4All project

Background: Choosing the most adequate measure of patient -reported outcomes (PROs) for a specific medical condition is not straightforward. This study aimed to develop a comprehensive archive of patient -reported outcome measures (PROMs), observer -reported outcome measures (ObsROMs) and caregiver -reported outcome measures (CROMs) in oncology and identify their main characteristics and target outcome domains. Materials and methods: As part of the Italian PRO4All Project, we retrieved questionnaires through an extensive search of online databases. We developed a data extraction form to collect information on cancer type, questionnaire variant(s), recall period, and scoring system. We performed a content analysis of the questionnaires to assign each item a specific outcome domain according to a predefined 38 -item taxonomy. Results: A total of 386 PROMs (n = 356), ObsROMs (n = 13) and CROMs (n = 17) were identified and described; of these, 358 were also analyzed in their content. 47.3 % of the instruments were cancer type -specific, 45.1 % were generic for cancer and 7.9 % were developed for the general population but also recommended in oncology. The great majority (92.2 %) were patient -reported. In 50.3 % the recall period was "last week". The mean number of items per questionnaire was 22.0 (range: 1-130). 7794 items were assigned an outcome domain, the most frequent being emotional functioning/wellbeing (22 %), physical functioning (15.7 %), general outcomes (10.1 %) and delivery of care (8.9 %). Conclusions: There are a variety of patient and caregiver -reported measures in oncology. This archive can guide researchers and practitioners in selecting the most suitable measures and fostering a patient -centered approach in clinical trials, clinical practice, and regulatory activities.