Since the 1970s, Italian pediatric oncologists have collaborated through the Italian Association for Pediatric Hematology Oncology (AIEOP) network using a common centralized system for the registration of childhood cancer, known as Model 1.01 (Mod. 1.01). In this study, we report on recruitment trends, extra-regional migration and changes in outcome over time in the Italian population of children (0-14 years) and adolescents (15-19 years) registered and treated within the national AIEOP network in the period between 1989 and 2017. In almost 30 years, a cohort of 43,564 patients with a neoplasia diagnosis was registered in Mod. 1.01. The analysis of national extra-regional migration showed that patients tend to migrate from the South to the North and, to a lesser extent, to the Center of the country. During the study period, migration apparently decreased, especially for lymphohematopoietic diseases, whereas it remained substantial for solid tumors. Our data showed a progressive and significant increase in the cumulative survival 5 years after diagnosis since the 1990s, reaching almost 84% for all patients diagnosed in the last decade. Survival rates of Mod. 1.01 patients are similar to those provided by the main national and international reports showing childhood cancer surveillance estimates. The AIEOP Mod 1.01 has proved to be an invaluable tool from both an epidemiological and a health policy point of view, allowing us, in this study, to examine the survival experience of the largest cohort of Italian pediatric cancer patients with a very long follow-up.Reliable and harmonized cancer registration is key for monitoring progress towards tracking all cancer cases within a population and for informing strategic planning and policy-making. Here, the authors describe the largest existing Italian cohort of pediatric and adolescent cancer patients over a period of 30 years by analyzing recruitment trends, extra-regional migration phenomena, and changes in outcome over time. The study illustrates the Italian Association for Pediatric Hematology Oncology (AIEOP)'s hospital registry as a valid tool for contributing to epidemiological research and for monitoring and improving the survival of children and adolescents with cancer in Italy. image
Survival rates and extra‐regional migration patterns of children and adolescents with cancer in Italy: The 30‐year experience of the Italian Association of Pediatric Hematology and Oncology (AIEOP) with the Italian hospital‐based registry of pediatric cancer (Mod. 1.01)
Quarello, Paola;Mosso, Maria Luisa;Milani, Lorenzo;Rosso, Tiziana;Maule, Milena;Fagioli, FrancaLast
2024-01-01
Abstract
Since the 1970s, Italian pediatric oncologists have collaborated through the Italian Association for Pediatric Hematology Oncology (AIEOP) network using a common centralized system for the registration of childhood cancer, known as Model 1.01 (Mod. 1.01). In this study, we report on recruitment trends, extra-regional migration and changes in outcome over time in the Italian population of children (0-14 years) and adolescents (15-19 years) registered and treated within the national AIEOP network in the period between 1989 and 2017. In almost 30 years, a cohort of 43,564 patients with a neoplasia diagnosis was registered in Mod. 1.01. The analysis of national extra-regional migration showed that patients tend to migrate from the South to the North and, to a lesser extent, to the Center of the country. During the study period, migration apparently decreased, especially for lymphohematopoietic diseases, whereas it remained substantial for solid tumors. Our data showed a progressive and significant increase in the cumulative survival 5 years after diagnosis since the 1990s, reaching almost 84% for all patients diagnosed in the last decade. Survival rates of Mod. 1.01 patients are similar to those provided by the main national and international reports showing childhood cancer surveillance estimates. The AIEOP Mod 1.01 has proved to be an invaluable tool from both an epidemiological and a health policy point of view, allowing us, in this study, to examine the survival experience of the largest cohort of Italian pediatric cancer patients with a very long follow-up.Reliable and harmonized cancer registration is key for monitoring progress towards tracking all cancer cases within a population and for informing strategic planning and policy-making. Here, the authors describe the largest existing Italian cohort of pediatric and adolescent cancer patients over a period of 30 years by analyzing recruitment trends, extra-regional migration phenomena, and changes in outcome over time. The study illustrates the Italian Association for Pediatric Hematology Oncology (AIEOP)'s hospital registry as a valid tool for contributing to epidemiological research and for monitoring and improving the survival of children and adolescents with cancer in Italy. imageFile | Dimensione | Formato | |
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