: The key goal in lung donation remains the improvement of graft preservation with the ultimate objective of increasing the number and quality of lung transplants (LTx). Therefore, in recent years the field of graft preservation focused on improving outcomes related to solid organ regeneration and restoration. In this contest Ex-Vivo Lung Perfusion (EVLP) plays a crucial role with the purpose to increase the donor pool availability transforming marginal and/or declined donor lungs suitable for transplantation. Aim of this proof of concept is to test the safety, suitability and feasibility of a new tilting dome for EVLP designed considering the dorsal lung areas as the "Achilles' heel" of the EVLP due to a more fluid accumulation than in the supine standard position.

Orthostatic Ex-Vivo Lung Perfusion (EVLP): A Proof of Concept

Boffini, Massimo;Costamagna, Andrea;Marro, Matteo;Simonato, Erika;Cassoni, Paola;Bertero, Luca;Fanelli, Vito;Brazzi, Luca;Rinaldi, Mauro
2024-01-01

Abstract

: The key goal in lung donation remains the improvement of graft preservation with the ultimate objective of increasing the number and quality of lung transplants (LTx). Therefore, in recent years the field of graft preservation focused on improving outcomes related to solid organ regeneration and restoration. In this contest Ex-Vivo Lung Perfusion (EVLP) plays a crucial role with the purpose to increase the donor pool availability transforming marginal and/or declined donor lungs suitable for transplantation. Aim of this proof of concept is to test the safety, suitability and feasibility of a new tilting dome for EVLP designed considering the dorsal lung areas as the "Achilles' heel" of the EVLP due to a more fluid accumulation than in the supine standard position.
2024
37
13178
13184
EVLP; animal model; lung transplant; organ preservation; perfusion
Boffini, Massimo; Costamagna, Andrea; Marro, Matteo; Simonato, Erika; Cassoni, Paola; Bertero, Luca; Fanelli, Vito; Barbero, Cristina; Brazzi, Luca; R...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/2006191
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