The NAPLS study provides valuable insights into prescribing patterns among antipsychotic (AP)–naïve CHR-P youth. Its exclusive focus on AP-naïve participants reflects not merely a methodological choice, but the culmination of a decade-long refinement in understanding the prognostic implications of AP exposure. Initiation of AP treatment serves as a proxy for greater clinical severity, underscoring the need for transparent handling of pharmacological exposures in CHR-P modeling.
Connecting the empirical dots on antipsychotic exposure and treatment in clinical high-risk for psychosis
Preti, AntonioLast
2025-01-01
Abstract
The NAPLS study provides valuable insights into prescribing patterns among antipsychotic (AP)–naïve CHR-P youth. Its exclusive focus on AP-naïve participants reflects not merely a methodological choice, but the culmination of a decade-long refinement in understanding the prognostic implications of AP exposure. Initiation of AP treatment serves as a proxy for greater clinical severity, underscoring the need for transparent handling of pharmacological exposures in CHR-P modeling.
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