Precision cross-sections for advancing cosmic-ray physics and other applications: A comprehensive programme for the next decade

Cosmic-ray physics in the GeV-to-TeV energy range has entered a precision era thanks to recent data from space-based experiments. However, the poor knowledge of nuclear reactions, in particular for the production of antimatter and secondary nuclei, limits the information that can be extracted from these data, such as source properties, transport in the Galaxy and indirect searches for particle dark matter. The Cross-Section for Cosmic Rays at CERN workshop series has addressed the challenges encountered in the interpretation of high-precision cosmic-ray data, with the goal of strengthening emergent synergies and taking advantage of the complementarity and know-how in different communities, from theoretical and experimental astroparticle physics to high-energy and nuclear physics. In this paper, we present the outcomes of the third edition of the workshop that took place in 2024. We present the current state of cosmic-ray experiments and their perspectives, and provide a detailed road map to close the most urgent gaps in cross-section data, in order to efficiently progress on many open physics cases, which are motivated in the paper. Finally, with the aim of being as exhaustive as possible, this report touches several other fields – such as cosmogenic studies, space radiation protection and hadrontherapy – where overlapping and specific new cross-section measurements, as well as nuclear code improvement and benchmarking efforts, are also needed. We also briefly highlight further synergies between astroparticle and high-energy physics on the question of cross-sections.