How I manage mycosis fungoides and Sézary syndrome: Current controversies and unmet needs

Mycosis fungoides and Sézary syndrome represent the most common types of cutaneous T-cell lymphoma. This series provides an updated perspective on their management, integrating new evidence on pathophysiology and therapeutic advances. Prompt recognition of early blood involvement and new prognostic models incorporating large-cell transformation have shown their importance in complementing the current staging. New monoclonal antibodies have represented a breakthrough in the management, though allogeneic transplantation remains the only potentially curative option, with growing evidence on its indications. Despite this therapeutic progress, the optimal sequencing of treatments, the selection of patients for transplantation and maintenance strategies remain unmet needs.