A new series of nonsteroidal antiinflammatory drugs (NSAIDs) obtained by linking ibuprofen to selected furoxan moieties and to related furazans were synthesized and tested for their antiinflammatory, antiaggregatory, and ulcerogenic properties. All the derivatives are endowed with antiinflammatory activity comparable to that of ibuprofen, but, unlike this drug, they display reduced acute gastrotoxicity. The masking of the ibuprofen-free carboxylic group seems to be principally at the basis of this reduced topical irritant action. The two furoxan derivatives 8 and 9 also trigger potent antiaggregatory effects, principally as a consequence of their NOdonor ability.

A new class of ibuprofen derivatives with reduced gastrotoxicity

LOLLI, Marco Lucio;CENA, Clara;MEDANA, Claudio;LAZZARATO, Loretta;FRUTTERO, Roberta;GASCO, Alberto
2001

Abstract

A new series of nonsteroidal antiinflammatory drugs (NSAIDs) obtained by linking ibuprofen to selected furoxan moieties and to related furazans were synthesized and tested for their antiinflammatory, antiaggregatory, and ulcerogenic properties. All the derivatives are endowed with antiinflammatory activity comparable to that of ibuprofen, but, unlike this drug, they display reduced acute gastrotoxicity. The masking of the ibuprofen-free carboxylic group seems to be principally at the basis of this reduced topical irritant action. The two furoxan derivatives 8 and 9 also trigger potent antiaggregatory effects, principally as a consequence of their NOdonor ability.
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L. LOLLI; C. CENA; C. MEDANA; L. LAZZARATO; G. MORINI; G. CORUZZI; S. MANARINI; R. FRUTTERO; A. GASCO
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/21478
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