We report a photocatalyst-free racemization of 1-arylethanols using substoichiometric diphenyl disulfide under purple light irradiation. Spectroscopic and computational studies suggest aggregation-enabled activation of the disulfide. The preliminary integration with Candida antarctica lipase B into a photobiocatalytic dynamic kinetic resolution on electron-rich 1-arylethanols, highlights the potential of sulfur radical chemistry in hybrid catalytic systems.
Diphenyl Disulfide‐Promoted Racemization of 1‐Arylethanols for Photobiocatalytic Dynamic Kinetic Resolution
Parisotto, Stefano
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2026-01-01
Abstract
We report a photocatalyst-free racemization of 1-arylethanols using substoichiometric diphenyl disulfide under purple light irradiation. Spectroscopic and computational studies suggest aggregation-enabled activation of the disulfide. The preliminary integration with Candida antarctica lipase B into a photobiocatalytic dynamic kinetic resolution on electron-rich 1-arylethanols, highlights the potential of sulfur radical chemistry in hybrid catalytic systems.
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