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EnglishThe study of T regulatory cells (T reg cells) has been limited by the lack of specific surface markers and an inability to define mechanisms of suppression. We show that the expression of CD39/ENTPD1 in concert with CD73/ecto-5'-nucleotidase distinguishes CD4(+)/CD25(+)/Foxp3(+) T reg cells from other T cells. These ectoenzymes generate pericellular adenosine from extracellular nucleotides. The coordinated expression of CD39/CD73 on T reg cells and the adenosine A2A receptor on activated T effector cells generates immunosuppressive loops, indicating roles in the inhibitory function of T reg cells. Consequently, T reg cells from Cd39-null mice show impaired suppressive properties in vitro and fail to block allograft rejection in vivo. We conclude that CD39 and CD73 are surface markers of T reg cells that impart a specific biochemical signature characterized by adenosine generation that has functional relevance for cellular immunoregulation.
Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression / DEAGLIO S; DWYER KM; GAO W; FRIEDMAN D; USHEVA A; CHEN JF; ENJYOJI K; ERAT A; LINDEL J; OUKKA M; KUCHROO VK; STROM TB; ROBSON SC. - In: JOURNAL OF EXPERIMENTAL MEDICINE. - ISSN 0022-1007. - 204(6)(2007), pp. 1257-1265.
| Titolo: | Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression |
| Autori Riconosciuti: | |
| Autori: | DEAGLIO S; DWYER KM; GAO W; FRIEDMAN D; USHEVA A; CHEN JF; ENJYOJI K; ERAT A; LINDEL J; OUKKA M; KUCHROO VK; STROM TB; ROBSON SC |
| Data di pubblicazione: | 2007 |
| Abstract: | The study of T regulatory cells (T reg cells) has been limited by the lack of specific surface markers and an inability to define mechanisms of suppression. We show that the expression of CD39/ENTPD1 in concert with CD73/ecto-5'-nucleotidase distinguishes CD4(+)/CD25(+)/Foxp3(+) T reg cells from other T cells. These ectoenzymes generate pericellular adenosine from extracellular nucleotides. The coordinated expression of CD39/CD73 on T reg cells and the adenosine A2A receptor on activated T effector cells generates immunosuppressive loops, indicating roles in the inhibitory function of T reg cells. Consequently, T reg cells from Cd39-null mice show impaired suppressive properties in vitro and fail to block allograft rejection in vivo. We conclude that CD39 and CD73 are surface markers of T reg cells that impart a specific biochemical signature characterized by adenosine generation that has functional relevance for cellular immunoregulation. |
| Editore: | Rockefeller University Press:1114 First Avenue, Fourth Floor:New York, NY 10021:(212)327-8572, EMAIL: rupcd@rockvax.rockefeller.edu, INTERNET: http://www.rockefeller.edu/rupress, Fax: (212)327-7944 |
| Volume: | 204(6) |
| Pagina iniziale: | 1257 |
| Pagina finale: | 1265 |
| Digital Object Identifier (DOI): | 10.1084/jem.20062512 |
| URL: | http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=2118603&blobtype=pdf |
| Parole Chiave: | regulatory T cells; ectoenzymes; cd39 |
| Rivista: | JOURNAL OF EXPERIMENTAL MEDICINE |
| Appare nelle tipologie: | 03A-Articolo su Rivista |
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